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KMID : 0374019890120030145
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Ewha Medical Journal
1989 Volume.12 No. 3 p.145 ~ p.150
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Study on Mixed Function and Lipid Peroxidation of Neonatal Hepatic Microsomes after Exposure to Alcohol During the Fetal and Lactating Period
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Abstract
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Maternal ingestion of alcohol produce not only change of drug metabolism L jt also proliferation of hepatic smooth-endoplasmic reticulum and many developmental defects of-the central nervous
system.
The.present.investigattion examined the effects of maternal consumption of alcohol during pregnancy and/or lactation the activities of electron transfer- components, mixed function monooxygenase, UDP-glucuronosyltransferase and lipid peroxidation of neonatal rat liver microsomes.
Normal group consisted of neonatal rats whose mothers received standard chow and water. The subject of experimental group were neonatal rats whose mothers were exposed to alcohol during pregnancy and lactation(3 weeks).
The results were obtained as follows
The activities of the electron transfer system, such as cytochrome P450, NADPH-cytochrome C reductase were increased in hepatic microsomes of experimental group.
The activities of the mixed function monooxygenase, p-nitroanisole-0-demethylase and the conjugated enzyme, UDP-glucuronosyltransferase were increased in hepatic microsomal experimental group. There was no significant differences between the formation of lipid peroxide of normal and experime-
ntal group.
These results suggest that prenatal exposure to alcohol are influenced by disturb of liver microsomal drug metabolism, especially during the fetal period.
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